Sedating antidepressants sleep
For some antidepressants, monitoring blood levels may help determine the range of effectiveness and to what extent dosage can be adjusted to help reduce side effects.
Rarely, antidepressants can cause serious side effects that need to be treated right away.
The most common side effects are drowsiness, fatigue, dizziness, dry mouth, and headache. Cyclobenzaprine has structure and pharmacological properties quite similar to amitriptyline, which may partly account for its sedating properties.
Currently experts do not know exactly how this drug works.
Cyclobenzaprine relieves skeletal muscle spasms of local origin without interfering with muscle function by acting within CNS at brain stem (reduces tonic somatic motor activity influencing both alpha and gamma motor neurons).
Currently, trazodone is the second most commonly prescribed treatment for insomnia.
Trazodone is often used as a hypnotic for sleep difficulties even in non-depressed insomniacs.
However, genetic testing is a part of — not a replacement for — a thorough psychiatric exam and clinical decisions.